Multivariate analysis of a tissue CEA, TPA, and CA 19.9 quantitative study in colorectal cancer patients

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Abstract
Eproducible, and standardizable. The tissue marker concentration was analyzed by means of the multivariate discriminant analysis, to evaluate the risk of relapse in each patient; the tumor CEA (CEAT) showed the best discriminant capacity (P=.005). The relative Fisher function provided a reliable prognostic patient index, independently of other recognized prognostic factors (Dukes' stage and cellular differentiation grade). The Cox model showed a statistical significance analyzing the tumor (T) and healthy mucosa (M) CEA values (P=.001 and P=.006, respectively). The combination of these two variables allowed for identification of three classes of patients according to CEA T and M threshold values of 216 and 85 ng/mg of protein, respectively, and different disease-free curves were obtained for each group. The two-year disease-free rate was 81 percent for patients with low values of both CEA T and M, and 21.4 percent for the group with both values above these thresholds (P=.0008). In the third class (CEA T or M higher than the reported cut-off levels), the two-year disease-free rate was 65.9 percent. Read at the 32nd World Congress of Surgery, Sydney, Australia, September 20 to 26, 1987. Partially supported by C.N.R. Progetto Finalizzato Oncologia, grant no. 84.00849.44. © The ASCRS 1989...

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