Human Recombinant Interferon Alpha-2a Inhibits Angiogenesis of Chick Area Vasculosa in Shell-Less Culture
- 1 January 1996
- journal article
- research article
- Published by S. Karger AG in International Journal of Microcirculation
- Vol. 16 (4) , 165-169
- https://doi.org/10.1159/000179169
Abstract
In vivo suppression of neovascularization by in situ administration of human recombinant interferon α2a (hrlFN-α2a) was tested on the chick embryo area vasculosa (AV). Methylcellulose discs, each containing 5 IU of hrlFN-α2a were implanted onto the AV at Hamburger-Hamilton (HH) stage 13, and inhibition of blood vessel growth was morphometrically evaluated between HH stages 20 and 27. Our results show: (i) a decreased extent of the AV; (ii) a decreased AV total vessel length; (iii) modified percent ratios of different classes of AV vessels having a definite length. The observed effects of treating with hrlFN-α2a are likely attributable to inhibition of endothelial cell proliferation.Keywords
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