Influence of plasma osmolarity on the rheology of human blood.

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Abstract
Suspensions of human red cells obtained from donor blood drawn into ACD [acid citrate dextrose] bags, then remixed into citrated plasma of various osmotic pressures, were examined in both Couette and capillary viscometers. It was found that variation of the osmotic pressure of the suspending media causes profound changes in the Theological properties of red cell suspensions. Hypotonic media result in increased yield shear stresses, while hypertonicity decreases this value. The viscosity of these suspensions at finite shear rates is also influenced by osmotic pressure and is, in general, increased in hypertonic media and decreased in hypotonic media. These changes appear to be related to the size, shape, and mechanical properties of the erythrocytes in these nonisotonic media.

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