Targeted Screening for Elongation Factor Tu Binding Antibiotics.
- 1 January 1997
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 50 (1) , 22-26
- https://doi.org/10.7164/antibiotics.50.22
Abstract
The development of a screen targeted to antibiotics which bind elongation factor Tu (EF-Tu) is described. The method was based on selection of antimicrobial activities which were antagonized by exogenous EF-Tu. Kirromycin, a known inhibitor of EF-Tu, was positive in this screen. Among 47,000 microorganisms screened, several producers of kirromycin-type antibiotics were detected and the novel antibiotics GE2270 and GE37468 were discovered. These thiopeptide molecules constitute, along with amithiamycin, a novel class of antibiotics acting on EF-Tu.Keywords
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