Determination of Folate Vitamers in Human Serum by Stable-Isotope-Dilution Tandem Mass Spectrometry and Comparison with Radioassay and Microbiologic Assay
Open Access
- 1 February 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 50 (2) , 423-432
- https://doi.org/10.1373/clinchem.2003.026955
Abstract
Background: Current clinical methods for folate give different results and cannot measure the various forms of folate. We developed an isotope-dilution tandem mass spectrometric method coupled to liquid chromatography (LC/MS/MS) as a candidate reference method for 5-methyltetrahydrofolic acid (5MeTHF), 5-formyltetrahydrofolic acid (5FoTHF), and folic acid (FA) in human serum.Keywords
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