Effects of hepatic denervation on the anorexic response to epinephrine, amphetamine, and lithium chloride: A behavioral identification of glucostatic afferents.
Ip injections of epinephrine (20, 40, 80, and 160 μg/kg) and amphetamine (.1, .2, and .4 mg/kg) were administered to 27 male Long-Evans hooded rats with various forms of hepatic denervation. Results suggest that the major component of hepatic metabolic afferent fibers travels from the liver, through the celiac ganglion, and into the esophageal vagal trunks where they ascend to the brain. The anorexic action of amphetamine appears to result from a centrally induced sympathetic action on the liver. (35 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)