Growth Inhibitory Effects of Transforming Growth Factor-β1 in vivo

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Abstract
Transforming growth factor-beta (TGF-β) can reversibly inhibit the in vitro proliferation of murine and human haemopoietic progenitors and. some of their more developmentally restricted progeny. Using an assay for measuring day 8 and day 11 CFU-S, TGF-β caused a gradual decline in the number of CFU-S undergoing DNA synthesis so that after 5 days of daily treatment only quiescent cells were found. Release of this growth inhibition was seen within 24 hours post-treatment with recovery of all progenitors to normal levels. Similar inhibitory effects of TGF-β were seen on the cells of the intestinal epithelium, indicating that TGF-β is a general stem cell growth inhibitor. These results suggest that TGF-β can be used as a cytostatic agent to protect normal stem cells in patients being treated with cell cycle-specific cytotoxic agents.

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