Glycoprotein and Collagen Metabolism in the Dermis of Hypophysectomized Rats

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Abstract
The effect of hypophysectomy on the concentration of total, salt soluble (0.15 and 0.5 [image] sodium chloride and 0.5 [image] sodium citrate) and insoluble collagen, nitrogen and hexosamine (Hex) in the skin of 60-day-old male rats was investigated. The pituitary glands were ablated at the 30th day of age. The total hydroxyproline (Hyx) concentration in hypophysectomized animals was lowered by about 25% and that of total Hex increased by 30% as compared to the controls. The Hex/Hyx ratio was 0. 047 for controls and 0.081 for hypophysectomized rats. Since the muco-polisaccharide (MPS) concentration was not modified in hypophysectomized rats [Nature (London) 200: 784, 1965], the higher Hex concentration appears due to increased glycoprotein content. Only about one fourth of the total Hex in intact and one fifth in hypophysectomized animals can be accounted for as MPS.

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