Synthesis of phosphorothloate-contaming DNA fragments by a modified bydroxybenzotriazole phospbotriester approach
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (23) , 9095-9110
- https://doi.org/10.1093/nar/12.23.9095
Abstract
The phosphorothioylating agent which was obtained by treating 2,5-dichlorophenyl phosphorodichloridothioate with 1-hydroxy-6-nitrobenzotriazole proved to be very effective for the synthesis in solution and on a solid support of phosphorothioate-containing DNA fragments.Keywords
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