In Vivo Activation of Macrophages but not Natural Killer Cells by Picolinic Acid (Pla)
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Immunopharmacology
- Vol. 6 (4) , 291-304
- https://doi.org/10.3109/08923978409028605
Abstract
Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.This publication has 15 references indexed in Scilit:
- Disproportionate accumulation of 18S and 28S ribosomal RNA in cultured normal rat kidney cells treated with picolinic acid or 5-methylnicotinamideExperimental Cell Research, 1981
- Enhanced Macrophage and Natural Killer Cell Antitumor Activity by Various Molecular Weight Maleic Anhydride Divinyl EthersJournal of Immunopharmacology, 1980
- Iron transport in NRK cells synchronized in G by picolinic acidCell Biology International Reports, 1978
- Iron: Possible cause of the G1 arrest induced in NRK cells by picolinic acidBiochemical and Biophysical Research Communications, 1977
- Interferon: An Inducer of Macrophage Activation by PolyanionsScience, 1977
- Control of growth by picolinic acid: Differential response of normal and transformed cellsProceedings of the National Academy of Sciences, 1977
- Transition metal ions induce cell growth in NRK cells synchronized in G1 by picolinic acidBiochemical and Biophysical Research Communications, 1977
- NRK cells synchronized in G1by picolinic acid are super-sensitive to prostaglandin E1stimulationFEBS Letters, 1977
- Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificityInternational Journal of Cancer, 1975