Genetic drift in a stock of laboratory mice
Open Access
- 1 January 1980
- journal article
- research article
- Published by SAGE Publications in Laboratory Animals
- Vol. 14 (1) , 11-13
- https://doi.org/10.1258/002367780780943015
Abstract
Genetic drift in an outbred stock of CFLP mice was monitored for 6 years using genetic polymorphism for glucose phosphate isomerase (GPI) and the shape of the mandible as genetic markers. Statistically significant drift was found in both characters. The cause of this drift was not determined, though it could have arisen as a result of genetic sampling during hysterectomy derivation. The use of inbred strains is recommended on theoretical grounds if long-term genetic constancy is needed.Keywords
This publication has 3 references indexed in Scilit:
- Isoenzymes of Phosphoglucose Isomerase in MiceNature, 1967
- SPONTANEOUS MUTATIONS AND MUTATION RATES IN THE HOUSE MOUSEGenetics, 1967
- The rate of genetic divergence of sublines in the C57BL strain of miceGenetics Research, 1962