THE EFFECTS OF TETHELIN

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Abstract
I have recently succeeded in isolating the growth-controlling principle from the anterior lobe of the pituitary body. The methods of isolating the substance, its chemical properties and physiologic actions and the evidences of its identity with the growth-controlling principle are contained in articles which have been published elsewhere.1Briefly summarized, however, the method of isolating the substance, which I term "tethelin" (from τεθνλώ[unk] growing), is as follows: The dried tissue of the anterior lobes of ox pituitaries is extracted with boiling absolute alcohol, and the solution is evaporated under reduced pressure until solid material begins to separate out on cooling. To this solution are added one and one-half times its volume of dry ether. The substance is thus precipitated, and after washing in large volumes of alcohol-ether mixture containing alcohol and ether in the abovementioned proportions, it may then be dried and pulverized. Tethelin is soluble in water to

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