SUPPRESSION BY 1,25(OH)2D3OF TRANSCRIPTION OF THE PRE–PR0PARATHYR0ID HORMONE GENE
- 1 December 1986
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 119 (6) , 2864-2866
- https://doi.org/10.1210/endo-119-6-2864
Abstract
When bovine parathyroid cells in culture are exposed to the active vitamin D metabolite 1,25(OH)2D3, a significant decrease in the steady-state levels of pre-proparathyroid hormone (pre-proPTH) mRNA occurs. The possibility that the fall in specific mRNA is due to a decrease in rate of transcription of the PTH gene was examined in this study. In the presence of 1,25(OH)2D3, there was a rapid and steady decline in PTH gene transcription rate which fell to a minimum of 10-15% of control at 24 h. The effect was observed at physiological levels (10-11 M) and was also fully reversible.This publication has 9 references indexed in Scilit:
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