Studies on the origin, processing and quality of crude drugs. II Pharmacological evaluation of the Chinese crude drug "Zhu" in experimental stomach ulcer. 2 Inhibitory effect of extract of Atractylodes lancea on gastric secretion.

Publisher Website
Google Scholar
Abstract
In order to identify the active principles in the 50% MeOH extract of the Chinese crude drug "Chang Zhu" (consisting of Atractylodes lancea rhizome), which has a preventive activity against experimental ulcerations, the effects of the benzene, methanol and aqueous fractions from 50% MeOH extract on gastric secretion in pylorus-ligated rats were investigated. The terpenes, .beta.-eudesmol and hinesol, contained in benzene fraction were found to be highly effective. .beta.-Eudesmol markedly inhibited ulcers in Shay rats, as well as histamine- and aspirin-induced gastric ulcers, and showed anti-secretory activity on gastric acid secretion stimulated by histamine in a perfused rat stomach preparation. The anti-ulcerogenic activity of 50% MeOH extract of Atractylodes lancea rhizome might be mainly attributable to the H2-antagonistic effect of .beta.-eudesmol.