In vitro isolation of a neutralization escape mutant of equine infectious anemia virus (EIAV)
- 1 September 1990
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 111 (3-4) , 275-280
- https://doi.org/10.1007/bf01311062
Abstract
Summary A neutralization escape mutant (A/1 E) of equine infectious anemia virus was isolated after 13 passages in cell culture in the presence of serum containing antibodies to type- and group-specific determinants of EIAV envelope glycoproteins. Loss of neutralization by the selecting serum correlated with loss of two epitopes in the major envelope glycoprotein gp90 of A/1 E which were present in a parallel variant isolated from a persistently infected pony.Keywords
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