INFLUENCE OF AGE AND SEX ON ACUTE TOXICITY OF 2 BARBITURICS ANESTHETICS ON RAT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 171  (4) , 846-849
Abstract
The acute toxicity of 2 barbiturate anesthetics (pentobarbital and thiopental) was highest in newborn rats. This was probably due to an immaturity of enzymatic biotransformation systems or to increased blood-brain barrier permeability.

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