Drug-Induced Catalepsy as Influenced by Psychostimulants, Apomorphine, L-Dopa, and Yohimbine

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Abstract
The anticataleptic activity of amphetamine, phenmetrazine, cocaine, apomorphine, yohimbine, and L-dopa wasdetermined in mice. Cataleptic states were produced using haloperidol, trifluoperazine, pilocarpine, nicotine, paraoxon, and tetrabenazineIn general, the anticataleptic activities of amphetamine, phenmetrazine, cocaine and yohimbine were of the same order of magnitude, nicotine catalepsy being preferentially antagonized by am hetamine and yohimbine. L-dopa was anticataleptic only when theanimals were pretreated with a monoamine oxydase inhibitor(iproniazid), but failed to antagonize the trifluoperazine catalepsy.Apomorphine exhibited very weak anticataleptic activity and was completely inactive against nicotine catalepsy.

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