Effects of Polyoxyethylene Sorbitan Monostearate (Tween 60) upon Experimental Oral Carcinogenesis in the Hamster

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Abstract
A study was undertaken to determine the suitability of the hamster cheek pouch for tumor -promotion experiments. Tween 60[long dash]polyoxyethylene sorbitan monostearate, a powerful tumor promoter for mouse skin[long dash]was the experimental agent utilized in conjunction with a carcinogen, 7,12-dimethylbenz/[alpha]/anthracene. Although a preliminary study indicated that Tween 60 by itself was unable to penetrate into the cheek pouch epithelium, the use of a carcinogen-Tween solution resulted in a marked decrease in the latent period for tumor induction compared with control tumors induced with DMBA alone. The results of these experiments indicate that a 2-stage phe-nomenon of carcinogenesis similar to that described for skin may be produced in the hamster cheek pouch.