Studies of Delayed-Action Medication

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Abstract
PROLIFERATION of delayed-action or sustained-release drugs is exceeded only by the claims made for them. These preparations are alleged to serve two purposes: a large single dose of drug may be given that, because of slowed release, will be therapeutically active longer, eliminating repeated dosage; and a sustained therapeutic level is attained, avoiding peaks of concentration with unwanted side effects or valleys with diminished therapeutic effects. For these benefits costs are considerably greater than for equal amounts of drug in the usual tablet form.Comparatively little investigative work has been done to verify these claims, a lack of which has . . .

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