Can a Cholesterol-Lowering Diet Cause Gallstones?

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Abstract
Ten years ago, Dayton and his colleagues initiated a randomized double-blind trial in 846 domiciled older men, aimed at testing whether a diet high in unsaturated fat would decrease the incidence of complications of atherosclerosis.1 A "control" group was instructed to eat meals containing chiefly animal fat. An "experimental" group ate similar meals in which 2/3 of the animal fat was replaced by vegetable fat. The number of meals eaten by each participant was recorded. During the study about 170 men in each group died, the majority from causes unrelated to atherosclerosis. Autopsies were carried out by members of the . . .

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