Properties of Fibrin Dissolved in Urea Solutions.

Abstract
Fibrin clots are soluble in concentrated urea solns. When urea is dialyzed out at pH 6.5, an opaque coarse type gel results; at pH 8, a fine type gel is formed. At 30% urea concn. the viscosity of fibrin and fibrinogen solns. were similar from pH 6 to 12. At 20% concn. the viscosity rose at pH values more alkaline than 7.6 and reached a max. value at 8.6; it then decreased to the original value. At 15% or lower, the increase in viscosity led to gelation; at high pH the gel redissolved.

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