The Combination of Rifampicin and other Antituberculous Agents in Chronic Murine Tuberculosis

Publisher Website
Google Scholar
Abstract
As a result of treatment with rifampicin, starting on the 11th day after infection with the Ravenel strain of Mycob. bovis used in these investigations, the disease passes into a chronic phase. The number (mode) of culturable organisms present in the lungs of the mice declines exponentially in the course of treatment with rifampicin in a dose of 40 mg/kg daily, so that the bacteriological findings in an increasing number of animals become negative after more than 100 days. After 150 days treatment with rifampicin (40 mg/kg) alone or rifampicin (40) in combination with streptomycin (250) or ethambutol (150), the majority of the mice are actually not yet bacteriologically sterile, since viable bacteria are again found in mice treated under the same conditions after a recuperation period of 50 or 100 days. In contrast, all animals treated with rifampicin (40) and INH (25) remain free from relapse. It may therefore be concluded that a special form of synergism takes place when these two drugs are given simultaneously.

This publication has 0 references indexed in Scilit: