COMPUTER-AUTOMATED STRUCTURE EVALUATION OF ANTILEUKEMIC 9-ANILINOACRIDINES
- 1 April 1987
- journal article
- research article
- Vol. 31 (4) , 457-476
Abstract
The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological end-points were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed.This publication has 32 references indexed in Scilit:
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