Relative Transfer of Estriol and Its Conjugates Across the Fetal Membranesin Vitro

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Abstract
The transport and metabolism of estriol, estriol-3-sulfate and estriol-16- glucosiduronate by human chorion and amnion have been studied in simple in vitro systems. Estriol is transferred more rapidly than its conjugates through both membranes. Transfer of all compounds is more rapid through amnion than chorion. Incubation of estriol sulfate with intact chorion or the homogenate results in significant hydrolysis. This is not true of amnion. Neither membrane sulfurylates estriol nor hydrolyzes the glucosiduronate. These observations are compared with those obtained previously with placenta and an explanation is offered for their similarity, based on common origin and function. (Endocrinology76: 722,1965)
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