Interaction of Neuropeptides with Human Mast Cells
- 1 January 1989
- journal article
- review article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 88 (1-2) , 70-78
- https://doi.org/10.1159/000234752
Abstract
Mast cells of human skin, but not lung, adenoids, tonsils, or intestine, release histamine in response to substance P, vasoactive intestinal polypeptide, and somatostatin. The substance P receptor of skin mast cells is not of the NK-1, NK-2 or NK-3 subtypes of smooth muscle. Time course and calcium dependency of release by peptides differed from anti-IgE. With anti-IgE, the molar ratios of histamine:PGD2:LTC4 generated by skin mast cells was 1,000:25:2, whereas with substance P these ratios were 1,000:1:0.1. Similar results were obtained with the other neuropeptides. The ability of peptides to stimulate skin mast cell histamine release suggests a mechanism whereby their release from dermal nerve endings is coupled to changes in micro-vasculature.Keywords
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