Interferon Induction by Viruses and Polynucleotides: A Differential Effect of Camptothecin
- 1 December 1975
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 29 (3) , 297-304
- https://doi.org/10.1099/0022-1317-29-3-297
Abstract
The plant alkaloid comptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly (rI).poly(rC) in chick and human cells. No effect of comptothecin could be detected on the multiplication of NDV, and it is concluded that the inhibition reflects a difference between interferon induction by viruses and by polynucleotides.Keywords
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