Effects of Intraperitoneally Injected Arginase on Growth of Mammary Carcinoma Implants in the Mouse

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Abstract
1. Animals receiving arginase treatment did not die of their implanted tumors during the 21-day period. The controls (Group “A”) and those receiving arginine (Group “B”) died within this period. 2. Those animals receiving arginine indicate a tumor length weight ratio increase of 7.9% over group “A”. 3. The group receiving arginase (Group “C”) exhibited a 28% decrease in size as compared to the controls in group “A”. 4. The ratio of tumor length to weight was 26% lower in the group receiving arginase. 5. Tumor specific volume (tumor length to weight) is offered as an accurate tumor measurement method.