UNIDIRECTIONAL THYROID GRAFT REJCTION BETWEEN B10.S AND B10.S(7R) MOUSE STRAINS

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Abstract
Reciprocal transplantation of D-region-histoincompatible thyroid grafts between mice of the B10.S and B10.S (7R) strains resulted in acceptance of all B10.S thyroid grafts by B10.S(7R) recipient mice and acute rejection of 93% of the thyroid grafts in the opposite direction. Evidence of expression of D region gene products on the surface of cells of B10.S thyroid grafts was supported by acute second-set rejecion of B10.S thyroid grafts by B10.S(7R) recipients preimmunized ith a B10.S skin graft. In vitro analysis of reciprocal immune responses between B10.S and B10.S(7R) mice demonstrated that the unidirectional thyroid graft rejection correlates with a relatively high frequency of cytotoxic T lymphocyte precursors (CTL-P). The frequency of B10.S splenic CTL-P reactive with B10.S(7R) (1/1131) was similar to that against the entire H-2 difference (i.e., B10.S anti-B10.BR, 1/776). HOwever, B10.S anti-B10.S(7R) CTL-P frequence yf B10.S(7R) anti-B10.S. The correlation between the high CTL-P frequencey and the ability to reject thyroid grafts, as well as possible causes for the difference in the reciprocal CTL-P freqeuncies are discussed.