Genetic Factors on Insulin Antibodies in Juvenile-Onset Diabetes
- 9 September 1976
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 295 (11) , 622
- https://doi.org/10.1056/nejm197609092951114
Abstract
To the Editor: The ability to develop antibody and cell-mediated immune responses to a variety of antigens is known to be under genetic control in animals.1 In men, immune responsiveness to certain antigens2 , 3 might also be governed by genes of the major histocompatibility complex. Since juvenile-onset diabetes mellitus is closely associated with HLA B8, BW15 and CW34 and humoral immune response to exogenous insulin is under control of genes linked to major histocompatibility complexes in mice5 , 6 we investigated the role of HLA genes on insulin antibody formation in juvenile-onset diabetes.IgG-insulin-binding capacity was studied by radioimmunoelectrophoresis,7 and 36 HLA . . .Keywords
This publication has 8 references indexed in Scilit:
- ENHANCED ANTIBODY RESPONSES IN ACTIVE CHRONIC HEPATITIS: RELATION TO HLA-B8 AND HLA-B12 AND PORTO-SYSTEMIC SHUNTINGThe Lancet, 1976
- Association of HL-A 5 and immune responsiveness in vitro to streptococcal antigens.The Journal of Experimental Medicine, 1975
- Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinantNature, 1975
- HL-A8, W15 and T3 in Juvenile Onset Diabetes MellitusHormone and Metabolic Research, 1975
- The clinical significance of highly purified pig-insulin preparationsDiabetologia, 1974
- Radioimmunoelectrophoresis in the Determination of Insulin Binding to IgG. Methodological StudiesHormone and Metabolic Research, 1973
- Clinical Aspects of Insulin–AntigenicityDiabetes, 1972
- Genetic Control of Specific Immune ResponsesPublished by Elsevier ,1969