Study of the Use of the Microwave Magnetic Field for the Rapid Inactivation of Brain Enzymes
Open Access
- 31 December 1983
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 35 (4) , 371-387
- https://doi.org/10.1254/jjp.35.371
Abstract
A new model of a microwave device was developed with a power of 10 kW at 2450 MHZ. A modified magnetic field distribution was used rather than the conventional electric field to accomplish even distribution of heating with minimum trauma and with a maximum certainity about enzyme inactivation. An integrated tuning system was used to increase efficiency and distribution of microwave energy absorption. This increased the ability of the instrument to inactivate the enzymes in the brains of mice and large rats. The time of irradiation for the rat was 600-900 ms and 100-330 ms for the mice. The animal chambers were designed so as not to impair breathing or to severely restrict movement. The effects of these improvements on microwave irradiation were confirmed by observation of brain appearance, effects on succinic dehydrogenase and cholinesterase activity, measurement of regional temperatures in the animal''s brain, thermograms of the brain, EM examination of brain tissue and measurement of endogenous acetylcholine and catecholamines.This publication has 39 references indexed in Scilit:
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