Physical Activity, Coronary Heart Disease, and Inflammatory Response

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Abstract
CARDIOVASCULAR diseases still are the leading cause of disability and death in the United States and other developed countries,1,2 and half of all cases are directly attributable to coronary heart disease (CHD). Landmark observational studies such as the Framingham Study3 have established a number of determinants and risk factors for atherosclerosis. In addition, the beneficial effect of physical activity on cardiovascular morbidity and mortality, and all-cause mortality is widely acknowledged.4 Debate is still ongoing about the amount and intensity of physical activity needed to achieve these benefits and about the role of work-related physical strain (WRPS).