[Molecular melting of DNA and the effect of the fine structure of fusion curves].

  • 1 November 1977
    • journal article
    • research article
    • Vol. 11  (6) , 1311-24
Abstract
The progress in understanding the phenomenon of molecular melting (helix -- coil transition) of DNA is considered. It is shown that the theory of DNA melting has reached such a stage of development when it is capable to compute melting profiles and denaturation maps for DNA with any given nucleotide sequence, on the base of a rather simple but adequate model of DNA. The effect of fine structure of the DNA melting profiles, its origin and possible applications are considered in greater detail. It is demonstrated that a direct comparison between experimental and theoretical melting profiles for the open replicative form of the upsilon X-174 phage DNA for which the complete nucleotide sequence has been published recently, confirms the theory and opens new possibilities for further investigation of equilibrium and kinetic properties of DNA molecules.

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