COMPARATIVE TRIAL ON THERAPEUTIC EFFECTIVENESS OF NEW ANTHELMINTIC DRUG - CICLOBENDAZOLE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 29  (4) , 423-426
Abstract
In a double-blind study in Cameroon the vermicidal effect of ciclobendazole, a new benzimidazole derivative, was evaluated and compared to mebendazole. Ciclobendazole and mebendazole were equally effective in the treatment of Ascaris and hookworm infestations. An increase in the dose of ciclobendazole from 600 to 1200 mg did not lead to an improvement in the effectiveness. When treating trichuriasis significantly better results were achieved with mebendazole (P = 0.01). Both drugs were tolerated equally well. Side effects, such as vomiting and diarrhea, only occurred in a small percentage of the patients.

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