PHOSPHOLIPID COMPOSITION AND [14C]GLYCEROL INCORPORATION INTO GLYCEROLIPIDS OF TOAD RETINA AND BRAIN
- 1 November 1976
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 27 (5) , 1051-1057
- https://doi.org/10.1111/j.1471-4159.1976.tb00307.x
Abstract
The phospholipid composition as well as the in vivo [14C]glycerol uptake in lipids was found to be similar in the toad brain and retina. The choroid lipid labeling was markedly different. An in vitro time-course study of [14C]glycerol incorporation in toad retina lipids disclosed that under the conditions of these experiments: (1) retina is able to rapidly synthetize phosphatidic acid from the radioactive precursor; (2) the sequence phosphatidic acid-diacylglycerol-triacylglycerol operates; (3) a high rate of phosphatidylinositol de novo biosynthesis takes place; (4) phosphoglycerides of choline and of ethanolamine are also heavily labeled after a lag period; (5) in vivo labeling profiles resembled those obtained in vitro mainly regarding phosphatidylinositol biosynthesis; and (6) the presence of glycerol kinase in the CNS is suggested.Keywords
This publication has 42 references indexed in Scilit:
- Incorporation of (3H)-arachidonic acid into cattle retina lipids: High uptake in triacylglycerols, diacylglycerols, phosphatidylcholine and phosphatidylinositolLife Sciences, 1975
- FREE FATTY ACIDS, DIACYL‐ AND TRIACYLGLYCEROLS AND TOTAL PHOSPHOLIPIDS IN VERTEBRATE RETINA: COMPARISON WITH BRAIN, CHOROID AND PLASMA12Journal of Neurochemistry, 1974
- EFFECT OF NEUROTRANSMITTERS ON PHOSPHOLIPID METABOLISM IN RAT CEREBRAL‐CORTEX SLICES—CELLULAR AND SUBCELLULAR DISTRIBUTION1Journal of Neurochemistry, 1974
- Phospholipase activity of retina and pigment epitheliumBiochemistry, 1973
- Vertebrate rod outer segment membranesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1973
- Fatty acid composition and level of diacylglycerols and phosphoglycerides in brain and retinaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- Positional distribution and turnover of fatty acids in phosphatidic acid, phosphoinositides, phosphatidylcholine and phosphatidylethanolamine in rat brain in vivoBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brainBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Turnover rates for glycerol, acetate and orthophosphate in phospholipids of the rat cerebral cortexBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- The biosynthesis of glycerides and glycerophosphatides by rabbit reticulocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967