Metabolism of nomifensine (Alival, Merital): isolation and identification of the conjugates of nomifensine‐14C from human urine.

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Abstract
1 It can be stated in regard to the metabolism of nomifensine that the metabolites and also the starting compound are present in alkaline urine almost completely in conjugated form. 2 The metabolites M I‐M III represent about 30% of the radioactivity excreted with urine. Two‐ thirds are N‐glucuronides and one‐third O‐glucuronides. 3 Nearly the entire remainder of the renally eliminated radioactivity in nomifensine which is present in conjugated form as N‐glucuronide. 4 Thus over 90% of the metabolites formed in man and excreted via urine have been identified.