Analysis of Polyethers by Isocratic HPLC with Universal Detectors. II. Quantitative Analysis and Determination of Molecular Weight Averages

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Abstract
It is shown, that LAC with coupled density and RI detection is a powerful tool in the determination of the MWD of polyethers. Polyethylene glycols and polypropylene glycols can be separated with very high resolution on a C-18 column in methanol-water under isocratic conditions. Peaks can be identified by the use of internal standards. A compensation of the molecular weight dependence of response factors is necessary only for very low molecular weight samples to yield accurate molecular weight averages. The results thus obtained can be used to evaluate the performance of SEC systems.