Application of HPLC to the Purification of Coupling Factor CF1From Spinach Chloroplasts and of Some of its Subunits

Abstract
A simple and rapid method of purification of coupling factor CF1, from spinach chloroplast crude extracts, is described, involving anion exchange HPLC on DEAE Pak. Separation of β, CF1 - δ, CF1-ε subunits is performed on the same column, after dissociation of the bound enzyme by extensive washing at low ionic strength. Purity of the fractions is checked by urea-SDS polyacrylamide electrophoresis and by fluorescence spectrometry.