Antimicrobial Surveillance of Haemophilus influenzae in the United States during 2000-2001 Leads to Detection of Clonal Dissemination of a β-Lactamase-Negative and Ampicillin-Resistant Strain
Open Access
- 1 March 2002
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 40 (3) , 1063-1066
- https://doi.org/10.1128/jcm.40.3.1063-1066.2002
Abstract
A 2000-2001 U.S. Haemophilus influenzae surveillance study ( n = 1,434) detected nine (0.6%) β-lactamase-negative and ampicillin-resistant (BLNAR) isolates collected from two different hospitals. The MICs of ampicillin for all nine isolates were 4 μg/ml, with results being reproducible; and all nine isolates were susceptible to amoxicillin-clavulanate, cefuroxime, cefprozil, macrolides, and fluoroquinolones. Pulsed-field gel electrophoresis of genomic DNA following Sma I digestion demonstrated identical patterns for each of the nine isolates, suggesting intra- and interhospital dissemination of a BLNAR clone.Keywords
This publication has 25 references indexed in Scilit:
- Antimicrobial Susceptibilities of 1,730 Haemophilus influenzae Respiratory Tract Isolates in Spain in 1998-1999Antimicrobial Agents and Chemotherapy, 2001
- Association of Amino Acid Substitutions in Penicillin-Binding Protein 3 with β-Lactam Resistance in β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzaeAntimicrobial Agents and Chemotherapy, 2001
- Worldwide Prevalence of Antimicrobial Resistance inStreptococcus pneumoniae, Haemophilus influenzae,andMoraxella catarrhalisin the SENTRY Antimicrobial Surveillance Program, 1997–1999Clinical Infectious Diseases, 2001
- A 1994–1995 survey of Haemophilus influenzae susceptibility to ten orally administered agents A 187 clinical laboratory center sample in the United StatesDiagnostic Microbiology and Infectious Disease, 1997
- Antimicrobial resistance among lower respiratory tract isolates of Haemophilus influenzae: results of a 1992-93 Western Europe and USA collaborative surveillance studyJournal of Antimicrobial Chemotherapy, 1996
- A survey of β-lactamase-producing Haemophilus influenzae an evaluation of 5750 isolatesDiagnostic Microbiology and Infectious Disease, 1995
- Epidemiology of Rob -Lactamase Among Ampicillin-Resistant Haemophilus influenzae Isolates in the United StatesThe Journal of Infectious Diseases, 1988
- National collaborative study of the prevalence of antimicrobial resistance among clinical isolates of Haemophilus influenzaeAntimicrobial Agents and Chemotherapy, 1988
- Prevalence of antimicrobial resistance among clinical isolates ofHaemophilus influenzaeDiagnostic Microbiology and Infectious Disease, 1986
- Isolation of an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzaeAntimicrobial Agents and Chemotherapy, 1980