The Effect of Sulphonamides and of Cooking or Grinding the Diet on the Excretion of Vitamins of the B Complex by the Refected Rat

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Abstract
Groups of rats were fed (1) a "refective diet" previously descr. by Coates, (2) the refective diet steamed with an equal wt. of water to gelatinize the starch, (3) the refective diet with 0.5% sulfathiazole and (4) with 0.5% succinyl-sulfathiazole. As previously noted, the refected rats can synthesize B vits., absorb enough of them for growth, and excrete measurable quantities in the urine of all except thiamine. Feeding of sulfonamides or breakdown of the starch prior to ingestion interfered with the refection condition by different mechanisms. It appears from this work that refection is dependent on the presence of undigested starch and starch-splitting organisms in the cecum, as well as the presence of other organisms (susceptible to sulfonamides) which carry out the symbiotic synthesis of the B vits.