Species differences of amobarbital metabolism: dihydroxyamobarbital formation
- 1 October 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (10) , 1167-1169
- https://doi.org/10.1139/y80-176
Abstract
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3′-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3′,4′-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.This publication has 1 reference indexed in Scilit:
- A method for studying drug metabolism in populations: Racial differences in amobarbital metabolismClinical Pharmacology & Therapeutics, 1979