The Effect ofIsonicotinyl Hydrazide on the Photosynthetic Incorporation of Radioactive Carbon Dioxide into Ethanol-Soluble Compounds ofChlorella

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Abstract
The effect of 10-2M. isonicotinyl hydrazide (isoniazid) on the incorporation of radioactive carbon dioxide by Chlorella during photosynthesis has been studied under steady-state conditions at two carbon dioxide concentrations. Isoniazid treatment results in increased radioactivity in sucrose, glycollic acid, and glycine and decreased radioactivity in sugar monophosphates, serine, and alanine. An unidentified compound which is strongly radioactive after short-term exposures to 14CO2 is present in isoniazid-treated cells. It is suggested that isoniazid pre-dominantly inhibits the conversion of glycine to serine.