Determination of a Unique and Immunodominant Epitope of Human T Cell Lymphotropic Virus Type I
Open Access
- 1 August 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 162 (2) , 353-357
- https://doi.org/10.1093/infdis/162.2.353
Abstract
The identification and isolation ofunique and immunogenic recombinant epitopes for human T celllymphotrophic virus (HTLV) type I might allow the development of an antibody-based assay to differentiate between HTLV-I and HTLV-II infections. 1b test the feasibility of this approach, an HTLV-I envelope epitope was isolated by immunoscreening of a Agtll recombinant HTLV-I DNA library with a human monoclonal antibody to HTLV-I. This recombinant epitope, MTA-4, when tested with sera from HTLV-I- or HTLV-II-infected individuals, was reactive with all HTLV-I and nonreactive with all HTLV-II antisera. These results indicate that MTA-4 is a unique and immunodominant epitope on HTLV-I and confirm the usefulness of human-derived monoclonal antibodies in an experimental approach to dissect the human humoral response to a viral pathogen.This publication has 13 references indexed in Scilit:
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