The metabolic fate of a herbicidal methylmercapto-s-triazine (cyanatryn) in the rat
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 10 (3) , 169-185
- https://doi.org/10.3109/00498258009033743
Abstract
1. A major route of metabolism of the methylmercaptotriazine herbicide cyanatryn involves S-oxygenation. 2. The S-oxide reacts spontaneously with glutathione affording a conjugate, which is eliminated in the bile, and a mercapturic acid which is eliminated in the urine. 3. A small proportion of the administered dose was covalently bound to a component of the blood, probably haemoglobin. This was shown to be dependent on the formation of the S-oxide and on the species of animal studied. 4. No reactivity of the S-oxide towards DNA in vivo, or in vitro could be demonstrated.This publication has 17 references indexed in Scilit:
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