Autoimmune Hemolytic Anemia with Anti Jka Specificity in a Patient Taking Aldomet

Abstract
Autoimmune hemolytic anemia (hemoglobin 5.2 g, reticulocyte count 31.0%) developed in a 53 yr old hypertensive woman who was taking Aldomet. The patient''s serum and the eluate prepared from her red blood cells contained an antibody with anti-Jka specificity. Rapid sustained improvement in the anemia occurred after cessation of Aldomet and a 2 wk course of prednisone therapy. Eight months later, anti-Jka was no longer detectable in the patient''s serum and the direct antiglobulin test was nonreactive.