Cisplatin-induced hypocalcemia and hypomagnesemia

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Abstract
Cisplatin (cis-diamminedichloroplatinum), a chemotherapeutic agent active against solid tumors, is a known cause of acute renal failure and renal tubular dysfunction. A case of renal magnesium wasting and hypomagnesemia in a 58 yr old women with genital pelvic malignancy was seen. Her initial manifestation was that of chronic symptomatic hypocalcemia of 4 mo. duration. The relatively reduced parathyroid hormone level in this patient and the possible sites of cisplatin-induced renal tubular dysfunction resulting in hypermagnesuria were evaluated. The importance of serially observing cisplatin-treated patients for the possible development of hypomagnesemic hypocalcemia is emphasized.

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