Type 2 Herpes Simplex Virus and Vulvar Carcinoma in Situ

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Abstract
Squamous-cell carcinoma in situ (CIS) of the vulva is now being reported at an increasing frequency. Its association with cervical CIS and invasive cancer has been recognized, and a "field effect" has been proposed to explain cases of CIS of the vulva, vagina, and cervix as responses to a common stimulus.1 , 2 Furthermore, genital CIS lesions are often multicentric. These disorders are especially alarming to patients, since CIS of the cervix can progress to invasive cancer. One topical and especially noteworthy candidate for the role of a common carcinogenic stimulus is herpes simplex virus Type 2 (HSV2), which has been associated . . .

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