Treatment of Uncomplicated Gonococcal Urethritis with Cefoxitin: Comparison with Penicillin

Publisher Website
Google Scholar
Abstract
Cefoxitin is a semisynthetic cephamycin with good in vitro activity against Neisseria gonorrhoeae. In a controlled clinical trial, 143 men with uncomplicated gonococcal urethritis received either cefoxitin (2.0 g intramuscularly rim] with 1.0 g of oral probenecid) or aqueous procaine penicillin G (4.8 × 106 units im with 1.0 g of oral probenecid). Of the 117 patients who returned for follow-up on days 3–13 after treatment, only 1.8% in the group given cefoxitin and 3.6% in the group given penicillin were not cured. The incidence of pain at the site of injection and rates of adverse reactions were similar for both groups. No hematologic, renal, or hepatic toxicity could be ascribed to either treatment regimen. Although none of the infections were due to β-Iactamase-producing gonococci, the results provide a basis for additional studies of the efficacy of cefoxitin in treatment of infections due to penicillinase-producing N. gonorrhoeae.

This publication has 0 references indexed in Scilit: