An Improved Reduction of the Ester Moiety in N-Substituted Pyroglutamates
- 1 September 1989
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 19 (16) , 2859-2868
- https://doi.org/10.1080/00397918908052674
Abstract
Lithium borohydride reduction of N-functionalized pyroglutamates failed to give the correspondence hydroxymethyl derivative. Reduction with lithium aluminium hydride bound to dry silica gel, however, gave excellent yields of chiral 5-hydroxymethyl-1-allyl-2-pyrrolidinones.Keywords
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