In vitro Enhancement of Adriamycin Cytotoxicity in Human Myeloid Leukemia Cells Exposed to Verapamil
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 41 (6) , 406-408
- https://doi.org/10.1159/000225865
Abstract
The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [3H]thymidine incorporation inhibition was used as a measure of cytotoxicity. The results clearly show an increase in the effectiveness of ADR when used along with VRP, which may be due to the changes in the cell membrane brought about by VRP.This publication has 17 references indexed in Scilit:
- A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsPublished by Elsevier ,2003
- Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycinBiochemical and Biophysical Research Communications, 1982
- OVERCOMING OF VINCRISTINE RESISTANCE IN P388 LEUKEMIA INVIVO AND INVITRO THROUGH ENHANCED CYTO-TOXICITY OF VINCRISTINE AND VINBLASTINE BY VERAPAMIL1981
- Pretherapeutic detection of tumour resistance and the results of tumour chemotherapyPublished by Elsevier ,1979
- METHODOLOGICAL APPROACH TO THE PREDICTION OF ANTI-CANCER DRUG EFFECT IN HUMANS1979
- INVIVO CHARACTERISTICS OF RESISTANCE AND CROSS-RESISTANCE OF AN ADRIAMYCIN-RESISTANT SUBLINE OF P388 LEUKEMIA1978
- LIPOSOMAL POTENTIATION OF ANTITUMOR ACTIVITY OF ALKYLATING DRUGS1976
- ACTIVITY OF ANTHRACYCLINES AGAINST AN ADRIAMYCIN (NSC-123127)-RESISTANT SUBLINE OF P388 LEUKEMIA WITH SPECIAL EMPHASIS ON CINERUBIN-A (NSC-18334)1976
- FURTHER STUDIES ON SELECTIVE CYTOTOXICITY OF TRITON WR-13391968
- RAPID MEMBRANE FILTRATION TECHNICS FOR STUDYING ACTION OF 6-THIOGUANINE ON TUMOR CELLS IN VITRO1963