Vitamin D3 and psoriasis: A randomized double-blind placebo-controlled study

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Abstract
A few open studies on small groups of patients have reported the efficacy of oral vitamin D3 in the treatment of psoriasis. To further characterize the therapeutic potential of this agent a placebo-controlled double-blind study was undertaken on a larger group of patients. Vitamin D3 (the active 1-α-hydroxy form) 1 μg/day and a placebo in a similar presentation were given in coded vials to 50 patients. Slight improvement was observed in 9 (45%) patients receiving vitamin D3 and 8 (38%) patients receiving placebo showed similar improvement, indicating that this regimen is not effective in the treatment of moderate to severe psoriasis.